Experimental Models of Parkinson’s Disease

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This detailed book focuses on cutting-edge methods for Parkinson’s disease (PD) research, such as the analysis of the prion-like properties of α-synuclein, mitochondrial functions related to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway related to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells), deep brain stimulation therapy, classic mitochondrial toxins related to PD, and genetic associations and screenings using mammalian and invertebrate genetic models of PD. The collection intends to serve as an introductory protocol book for basic research on PD pathogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Experimental Models of Parkinson's Disease is an ideal guide for researchers continuing to work toward making PD risk predictable and surmountable.

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ReiheMethods in Molecular Biology
ISBN 9781071614976
Sprache Englisch
Ausgabe 1st ed. 2021
Erscheinungsdatum 29.05.2022
Umfang 217 Seiten
Genre Medizin/Nichtklinische Fächer
Format Taschenbuch
Verlag Springer US
Herausgegeben von Yuzuru Imai
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