Variant Calling

Methods and Protocols

354 Seiten, Hardcover

Kurzbeschreibung des Verlags

This volume provides practical guidance on a variety of techniques and steps to ensure successful variant calling. Chapters detail methods for variant calling from single-nucleotide variants to structural variants, variant calling in specialized data types such as RNA-seq and UMI-tagged sequencing, alignment-free genotyping and SNP calling, variant detection in single-cell DNA sequencing data, variant annotation, and preanalytical quality control to ensure successful variant calling. Written in the format of the highly successful Methods in Molecular Biology  series, each chapter includes an introduction to the topic, lists step-by-step protocol to execute the algorithms, describes the input and output data, and includes tips on troubleshooting and known pitfalls.

 

Authoritative and cutting-edge, Variant Calling: Methods and Protocols  aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.  

• Reihe: Methods in Molecular Biology
• Themen: Mathematik und Naturwissenschaften Biologie, Biowissenschaften Biowissenschaften, allgemein Genetik (nicht-medizinisch)
• ISBN: 9781071622926
• Sprache: Englisch
• Erscheinungsdatum: 26.06.2022
• Größe: 25.4 x 17.8 cm
• Verlag: Springer US
• Herausgegeben von: Charlotte Ng, Salvatore Piscuoglio