Pharmacogenomics

Methods and Protocols

214 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

• Reihe: Methods in Molecular Biology
• ISBN: 9781617375712
• Sprache: Englisch
• Erscheinungsdatum: 19.11.2010
• Genre: Medizin/Pharmazie
• Verlag: Humana Press
• Herausgegeben von: Federico Innocenti