Molecular Dynamics and Optimization Studies of α-Synuclein Protein Structures

Mechanism Underlying the Parkinson’s Disease and Movement Disorders

von Jiapu Zhang

1864 Seiten, Mehrteiliges Produkt

Kurzbeschreibung des Verlags

Parkinson’s disease (PD), the second most common neurodegenerative disorder in human. The cause of PD is believed to involve genetic factors. At least 6 pathogenic genes have been associated with familial PD. α-Synuclein (αS) is the main component of the Lewy bodies that accumulate in the brains of people with PD. Misfolding of the αS protein has been implicated in the molecular chain of events leading to PD. This book studies wild type (WT) αS proteins and their (8) αS(1-140)-mutants by optimization and Molecular Dynamics (MD). In this book our systematic MD study of a wider range of mutants would provide some answers for genetic factors.

Numerous bindings of some segments of αS are also MD studied. Some fibrils leaded by aS misfolding are MD studied too.

This book is particularly valuable for professionals working in computing roles within computational biochemistry/biophysics, bioinformatics, etc. It serves as an accessible introduction and is an excellent resource for students.

• Reihe: Springer Series in Biophysics
• Themen: Mathematik und Naturwissenschaften Biologie, Biowissenschaften Molekularbiologie
• ISBN: 9783032212801
• Sprache: Englisch
• Erscheinungsdatum: 29.07.2026
• Größe: 23.5 x 15.5 cm
• Verlag: Springer International Publishing