New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids

von Ana Escribano Cuesta

195 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.

• Reihe: Springer Theses
• ISBN: 9783319033853
• Sprache: Englisch
• Erscheinungsdatum: 22.08.2015
• Genre: Chemie/Organische Chemie
• Verlag: Springer International Publishing