Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones

von Robert Doran

202 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

• Reihe: Springer Theses
• ISBN: 9783319370347
• Sprache: Englisch
• Erscheinungsdatum: 15.10.2016
• Genre: Chemie/Organische Chemie
• Verlag: Springer International Publishing