Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

von Stacey L. McDonald

144 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

• Reihe: Springer Theses
• Themen: Mathematik und Naturwissenschaften Chemie Organische Chemie Metallorganische Chemie
• ISBN: 9783319817675
• Sprache: Englisch
• Erscheinungsdatum: 22.04.2018
• Größe: 23.5 x 15.5 cm
• Verlag: Springer International Publishing