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| Reihe | Current Topics in Microbiology and Immunology |
|---|---|
| Themen | Medizin Klinische und Innere Medizin Krankheiten und Störungen Immunologie |
| ISBN | 9783540230908 |
| Sprache | Englisch |
| Erscheinungsdatum | 16.02.2005 |
| Größe | 241 x 160 mm |
| Verlag | Springer |
| Herausgegeben von | Rudolf Grosschedl, Harinder Singh |
| Lieferzeit | Lieferung in 7-14 Werktagen |
| Herstellerangaben | Anzeigen Europaplatz 3 | DE-69115 Heidelberg ProductSafety@springernature.com |
Eugeniawaspassionatelyinterestedinunderstandingthemolecular- sisofdevelopmentandchoseashermodelsystemthedevelopmentofB andTlymphocytes. Shebeganbystudyingthetranscriptionalregulation oftheTcell-specificgene,Thy-1,asagraduatestudentinFrankGrosveld s labatMillHill,London. Thereafter,sheturnedherattentiontothetopicof V(D)Jrecombination,firstasapostdoctoralfellowwithDavidBaltimore attheWhiteheadInstituteinCambridge,Massachusettsandsubsequently inherownlaboratoryatMountSinaiSchoolofMedicineinNewYorkCity. Eugeniamadefundamentaldiscoveriesconcerningthebiochemicalme- anismofthisreaction,andhowdefectsinitscentralenzymaticcom- nents,RAG1andRAG2,canleadtoahumanseverecombinedimmuno- ficiencydisorder,knownasOmennsyndrome. Atthetimeof herdeath, shehadbeenaHowardHughesMedicalInstituteinvestigatorforlessthan ayear,buthadalreadyassembledalaboratoryof15peopleworkingonan extensivearrayoftopicsinearlylymphocytedevelopmentandV(D)J- combination. Eugenialivedeachmomentofherlifewithanintensityfittingforthe cityinwhichshelived. LikeManhattan,shesleptlittle. Sheexpectedagreat dealofherself,andonlyalittlelessfromthosewithwhomsheworked. - geniaalsohadhighexpectationsforthescientificprocessandwasouts- keninherpraiseorcondemnationofthosewhometorfellshortofthose expectations. Shewasquicktoformanopinionanddevotedherselffe- ciouslytofriendshipsandhypotheses. PerhapsthegreatesttestimonytoEugeniaistheaffectionandreverence feltforherby themembersof herlab. Whilethisstemmedinnosmall partfrompredictablesources-herkeenmindandbroadknowledge-it founditsdeepestsourceinEugenia sabilitytotransmit,byexampleand word,her love of a life of learning and exploration. SandroSantigata,a graduatestudentinEugenia slab,capturedthiseloquentlyatthememorial serviceforEugeniaandAndrew,whenhesaid: VIII Obituary "Ifyouhaveeverbeenspellboundbyagreatstatue,enrapturedbyits strengthandvitality,enthralledbyitspurity,purposeandgraceandupli- edbythesenseofhopethatitsparkswithinyoursoul,thenyouhave- readyunderstoodwhyIadoredEu
| Reihe | Current Topics in Microbiology and Immunology |
|---|---|
| Themen | Medizin Klinische und Innere Medizin Krankheiten und Störungen Immunologie |
| ISBN | 9783540230908 |
| Sprache | Englisch |
| Erscheinungsdatum | 16.02.2005 |
| Größe | 241 x 160 mm |
| Verlag | Springer |
| Herausgegeben von | Rudolf Grosschedl, Harinder Singh |
| Lieferzeit | Lieferung in 7-14 Werktagen |
| Herstellerangaben | Anzeigen Europaplatz 3 | DE-69115 Heidelberg ProductSafety@springernature.com |
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