The Cerebral Perivascular Cells

von Michael Streppel, Orlando Guntinas-Lichius, Doychin N. Angelov, Wolfram F. Neiss, Michael Walther

104 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

1 Introduction.- 1.1 Antigen Presentation and Antigen Presenting Cells.- 1.2 Antigen Presentation within the CNS.- 1.3 Microglia Might Be the Cerebral Antigen Presenting Cells.- 1.4 Theories on the Antigen Presentation Site.- 1.5 Questions Still Open.- 1.6 Methodological Approach.- 2 Materials and Methods.- 2.1 Animals.- 2.2 Overview of Animal Experiments.- 2.3 Surgery.- 2.4 Number of Sprouting Neurons After Retrograde Tracing with HRP.- 2.5 Number of Surviving Neurons After Resection of the Facial Nerve.- 2.6 Neuronophagic Microglia Identified by Vital Labeling with Fluoro-Gold.- 3 Results.- 3.1 Resection of 10 mm of the Facial Nerve Causes a Slow Loss of Facial Motoneurons in the Adult Rat.- 3.2 No Breakdown of the Blood - Brain Barrier or Passage of Unprimed Lymphocytes into Brain Tissue After Facial Nerve Resection.- 3.3 Fluoro-Gold Labeling of Motoneurons, Phagocytic Microglia and Perivascular Cells.- 3.4 Time Course of Existence and Migration of Fluoro-Gold-Labeled Neuronophages.- 3.5 Immunocytochemistry of the Fluoro-Gold-Labeled Neuronophages.- 4 Discussion.- 4.1 Oligodendrocytes and Astrocytes Are Not the APC of the Brain.- 4.2 Microglia Are Not the APC of the Brain.- 4.3 The Perivascular Cells Are the APC of the Brain.- 5 Summary.- References.

• Reihe: Advances in Anatomy, Embryology and Cell Biology
• Themen: Mathematik und Naturwissenschaften Biologie, Biowissenschaften Biowissenschaften, allgemein Neurowissenschaften
• ISBN: 9783540646389
• Sprache: Englisch
• Erscheinungsdatum: 21.09.1998
• Größe: 235 x 155 mm
• Verlag: Springer