Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

von Colm Duffy

130 Seiten, Hardcover

Kurzbeschreibung des Verlags

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

• Reihe: Springer Theses
• Themen: Mathematik und Naturwissenschaften Chemie Organische Chemie
• ISBN: 9783642246319
• Sprache: Englisch
• Erscheinungsdatum: 05.01.2012
• Größe: 23.5 x 15.5 cm
• Verlag: Springer Berlin