PANCREATIC CANCER

A Contemporary Clinical Guide to Pathogenesis, Molecular Genetics, Diagnosis, Staging, Multimodal Treatment, and Patient Care

von Hugo L. Garcia MD.

558 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

PANCREATIC CANCER>Pancreatic cancer remains one of the most challenging malignancies in modern clinical medicine, requiring precise diagnostic evaluation, molecular characterization, careful staging, multidisciplinary treatment planning, and comprehensive patient-centered care. Pancreatic Cancer provides a contemporary clinical and translational overview of this complex disease, connecting fundamental tumor biology with practical approaches to diagnosis and management.

Beginning with pancreatic anatomy, epidemiology, risk factors, and disease development, this guide explores the molecular and cellular mechanisms underlying pancreatic carcinogenesis. It examines genetic and epigenetic alterations, oncogenic signaling, tumor suppressor pathways, precursor lesions, tumor heterogeneity, the tumor microenvironment, and experimental models that have shaped current understanding of pancreatic cancer.

The book then progresses through the clinical evaluation of suspected disease, including presenting features, laboratory assessment, imaging, tissue diagnosis, pathology, biomarkers, and differential diagnosis. Particular attention is given to contemporary staging and the clinically important distinction among resectable, borderline resectable, locally advanced, and metastatic disease, which directly influences treatment strategy.

Comprehensive treatment discussions address multidisciplinary management, including pancreatic surgery, systemic chemotherapy, radiation therapy, neoadjuvant and adjuvant strategies, targeted treatment, molecularly guided therapy, clinical trials, and approaches to recurrent or advanced disease. The text also considers hereditary cancer syndromes, germline and tumor testing, actionable molecular alterations, and the growing role of precision oncology.

Beyond tumor-directed therapy, the book addresses the broader needs of patients, including cancer-related pain, biliary and gastrointestinal complications, nutritional and pancreatic exocrine insufficiency, treatment-related effects, supportive and palliative care, and ongoing clinical monitoring.

With an emphasis on clear clinical reasoning, contemporary terminology, evidence-informed practice, and translational relevance, this book is designed to help readers understand not only what pancreatic cancer is, but how its biology, molecular profile, anatomical extent, and clinical presentation influence diagnostic and therapeutic decisions.

Pancreatic Cancer is a focused resource for physicians, surgeons, oncologists, gastroenterologists, radiologists, pathologists, advanced practice clinicians, medical trainees, researchers, and other healthcare professionals seeking a concise yet comprehensive perspective on one of the most demanding areas of gastrointestinal oncology.

Hugo L. Garcia, MDPhysician and Medical Author

• Reihe: Independently published
• ISBN: 9798176004854
• Sprache: Englisch
• Erscheinungsdatum: 21.09.2026
• Größe: 229 x 152 mm
• Verlag: Independently published