Neonatal and Pediatric Pharmacology with Pharmacogenomics and Precision Therapeutics

Evidence-Based Drug Therapy, Pharmacokinetics, and Clinical Applications in Infants and Children

von Gregory A Sutherland

434 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

Every year, preventable dosing errors harm infants and children because a drug regimen built for adults gets scaled down by weight alone, ignoring the genuine physiologic and genomic differences that separate a neonate from a miniature adult.You need dosing decisions that reflect real developmental pharmacokinetics, not linear extrapolation. Enzyme ontogeny, renal maturation, receptor density, and inherited metabolizer status all shift the safe and effective dose window in ways a standard adult-derived reference cannot capture.Without this framework, clinicians risk underdosing a renally cleared antibiotic in a preterm neonate, missing a CYP2D6 poor-metabolizer phenotype before an opioid order, or overlooking a TPMT or DPYD variant that turns a standard chemotherapy dose toxic.Neonatal and Pediatric Pharmacology with Pharmacogenomics and Precision Therapeutics gives you the evidence-based framework to prescribe with confidence across the full pediatric age spectrum for the 2026 edition: - Developmental pharmacokinetics and pharmacodynamics from extreme prematurity through adolescence- Clinical pharmacogenomics across CYP450 and non-CYP pathways, including TPMT, UGT1A1, G6PD, and DPYD- Organ-system pharmacotherapy for cardiology, infectious disease, neurology, oncology, endocrinology, and psychiatry- Medication safety, pharmacovigilance, and precision-therapeutic strategies including gene therapy and biomarker-guided dosingWritten by a practicing clinician, this reference pairs 50 detailed clinical illustrations with a companion QR-coded video course of more than 100 curated lectures, so every dosing principle in the text is reinforced with visual and spoken instruction.Stop guessing at pediatric doses. Start prescribing with the developmental and genomic precision your smallest patients deserve.

• ISBN: 9798192669495
• Sprache: Englisch
• Erscheinungsdatum: 14.08.2026
• Größe: 279 x 216 mm
• Verlag: Amazon Digital Services LLC - Kdp