Principles of Advanced Pharmacokinetics and Pharmacodynamics

Drug Disposition, Mechanisms of Action, PK/PD Modelling, Dose Optimization, and Evidence-Based Pharmacotherapy for Residents, Fellows, and Advanced Practice Clinicians

von Angelina Airey, Abigail Haddon

432 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

Move beyond memorising doses and learn to reason from exposure, patient physiology, and pharmacological effect.Principles of Advanced Pharmacokinetics and Pharmacodynamics is an advanced clinical reference for residents, fellows, pharmacists, advanced practice clinicians, and pharmacology trainees who need a connected understanding of how drugs move through the body, how concentration relates to response, and why standard dosing can produce different exposures across patients.Beginning with absorption, distribution, metabolism, and elimination, the book builds through compartmental and noncompartmental analysis, clearance, volume of distribution, half-life, bioavailability, nonlinear kinetics, hepatic and renal disposition, and transporter biology. It then links these principles to receptor pharmacology, concentration-effect models, population pharmacokinetics, Bayesian dose individualization, and therapeutic drug monitoring.Inside, readers will explore: - One-, two-, and multicompartment models, AUC, AUMC, mean residence time, accumulation, and steady state- Clinical interpretation of hepatic extraction, renal clearance, protein binding, dialysis, critical illness, and organ dysfunction- Emax, sigmoidal Emax, effect-compartment, indirect-response, exposure-safety, and integrated PK/PD models- Population PK, covariate modelling, Bayesian forecasting, and model-informed precision dosing- Therapeutic drug monitoring for vancomycin, aminoglycosides, immunosuppressants, antiepileptics, digoxin, lithium, antifungals, antivirals, and biologics- Pharmacokinetics in paediatric, geriatric, pregnant, obese, bariatric, neonatal, and critically ill populations- Drug-drug, drug-food, and drug-herb interactions; pharmacogenomics; PBPK modelling; drug development; antimicrobial PK/PD; and chronopharmacologyMechanistic explanations, equations, clinical applications, figures, and case-based reasoning help readers connect quantitative principles to professional decision-making. Chapters can be studied in sequence or consulted as focused references for advanced training and practice.This text is educational. Drug-specific dosing, monitoring, interaction, and treatment decisions must be checked against current labelling, formularies, institutional protocols, and clinical guidelines.

• ISBN: 9798193512509
• Sprache: Englisch
• Erscheinungsdatum: 18.08.2026
• Größe: 279 x 216 mm
• Verlag: Amazon Digital Services LLC - Kdp