LIQUID BIOPSY HEMATOLOGY

Circulating Tumor DNA And Exosomal Diagnostics In Blood Malignancies

von Jonas Edwards

266 Seiten, Taschenbuch

Kurzbeschreibung des Verlags

LIQUID BIOPSY HEMATOLOGYCirculating Tumor DNA And Exosomal Diagnostics In Blood Malignancies;

This is a definitive clinical and molecular guide to blood-based diagnostics in leukemia, lymphoma, and myeloma.For over a century, the bone marrow biopsy has been the unchallenged gatekeeper of hematologic diagnosis. It is painful, risky, and-most critically-static. It offers a single snapshot of diseases that evolve by the hour. Liquid Biopsy Hematology reveals how a simple blood draw is replacing that limitation with real-time molecular intelligence.This comprehensive volume bridges cutting-edge science with practical patient care, showing clinicians and laboratory scientists how to detect, monitor, and outmaneuver blood malignancies at the molecular level. Inside, you will discover:

- Why blood cancers are uniquely suited for liquid biopsy-and how ctDNA shedding, fragmentomics, and nucleosome positioning create information-rich signals invisible to conventional pathology.- The complete technology arsenal-from droplet digital PCR and BEAMing to UMI-based next-generation sequencing, methylation profiling, and exosome isolation by ultracentrifugation, SEC, and microfluidics.- Actionable clinical applications across the hematologic spectrum: NPM1 and FLT3-ITD MRD monitoring in AML; JAK2/CALR quantification in myeloproliferative neoplasms; CAPP-Seq and PhasED-Seq response assessment in DLBCL; exosomal PD-L1 prediction of immunotherapy response; and IGH rearrangement tracking in multiple myeloma.- How to navigate the "CHIP conundrum"-distinguishing age-related clonal hematopoiesis from active malignancy to prevent false-positive molecular relapse.- Regulatory and economic roadmaps: CLIA validation, FDA oversight, ELN 2025 MRD guidelines, reimbursement strategies, and ctDNA as a surrogate endpoint in adaptive clinical trials.- The future unfolding now: AI-driven fragmentomic pattern recognition, multi-omic integration of ctDNA/exosomes/CTCs, organoid models derived from exosomal cargo, and implantable biosensors for continuous cancer monitoring.

Illustrated with clinical case studies-including early molecular relapse detection, venetoclax resistance tracking, CAR-T resistance prediction, and CHIP versus tumor discrimination-this book equips hematologists, oncologists, molecular pathologists, and translational researchers with the knowledge to implement precision liquid biopsy in daily practice.Blood speaks. This book teaches you how to listen.

• Reihe: Independently published
• ISBN: 9798194607884
• Sprache: Englisch
• Erscheinungsdatum: 27.08.2026
• Größe: 229 x 152 mm
• Verlag: Independently published